Microbiology - Exam 4

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varicella zoster viral infection is what category of infection?

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Ch 14-16

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1

varicella zoster viral infection is what category of infection?

latent

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2

during the NETosis, neutrophils expel what to trap pathogens?

DNA

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3

which is “not” a benefit of our microbiome?

NOT more efficient use of ATP; IS better digestion, vitamine production, more efficient use of ATP

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4

these cells will cause allergic reactions in some individuals

mast cells

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5

the compound released by (mast cells) is a derivative of what amino acid?

histidine

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6

what protein makes skin repel water?

keratin

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7

when cells fuse to form one large multinucleated cell, it is called a ___?

syncytium

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8

Infants lack the ability to defend against what even using standard vaccination?

T-independent antigens

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9

Virally infect cells can sometimes use fake versions of what to elude the immune system?

MHCs

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10

Which bacterial genus occupies the normal gut microbiome?

all of the above (clostridium, lactobacillus, bactericides)

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11

which cytokine is anti-inflammatory?

IL-10

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12

true or false: lactobacillus increases the pH of the vagina to block pathogen growth

false

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13

which is *not* composed of a mucous membrane?

NOT the skin; IS esophagus, sinuses, eye

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14

what organelle is used for movement of phlegm?

the cilium

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15

which type of receptor is composed of a constant and variable region?

both of the above (T cell receptor & B cell receptor)

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16

true or false: inflammation is always caused by a pathogen

false

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17

which is “not” a component of the MAC?

NOT C5a; IS C6, C7, C9

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18

TLRs in endosomal lumen membranes detect what?

dsRNA

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19

Lectin receptors for pathogens often detect what monosaccharide component of a polysaccharide?

mannose

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20

this inflammasome is formed upon activation of what?

NOD-like receptors

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21

the interferon signaling cascade is most associated with what kind of infection?

viral

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22

which is “not” a mechanism for a bacterium to escape phagocytosis?

NOT destroying the lysosome; IS cleaving complement proteins, mimicking host cells, embedding Fc receptors in membrane

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23

which yeast is pathogenic to immunocompromised individuals?

candida albicans

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24

which cytokine induces apoptosis in neighboring cells?

TNFalpha

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25

which is a proinflammatory cytokine?

all of the above (TNFalpha, IL-6, IL-1)

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26

which is “not” a type of PRR?

NOT LAMP; IS MAMP, DAMP, NLRP

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27

which is “not” a form of activated macrophage?

M3

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28

giant cells are formed by fusion of what?

macrophages

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29

which is a form of inflammatory mediator?

prostaglandin

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30

during inflammation, blood vessels __ ?

dilate

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31

chronic inflammation can be induced by what?

all of the above (obesity, cancer, autoimmunity)

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32

the presence of bacteria in the blood stream is called what?

bacteremia

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33

effector proteins from a bacterium are injected through what system?

type III secretion system

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34

bacteria use what protein type to attach before colonization?

adhesins

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35

using the host cell’s actin cytoskeleton to induce endocytosis is called membrane ____?

ruffling

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36

the order or infectious disease progression begins with ___ and ends with __.

none of the above (CORRECT: incubation; convalescence)

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37

which immunoglobulin adheres to mucous membranes through secretion?

IgA

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38

which complement protein is an opsonin?

C3b

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39

which leukocyte is the first on the scene for an infection?

neutrophil

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40

what is not a sign of the inflammation?

NOT bruising; IS redness, swelling, pain

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41

what do antibodies recognize?

both of the above (epitopes & antigens)

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42

B cells and T cells gather in clusters in the ___ of a lymphatic organ.

germinal center

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43

which is a form of antigen presenting cell?

all of the above (B cell, macrophage, dendritic cell)

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44

true or false: central tolerance occurs in the spleen

false

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45

what kind of pathogen uses the answer to the above question to evade the immune system?

virus

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46

this protein is used to sequester iron away from microbes:

lactoferrin

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47

which is an antimicrobial peptide produced by our cells?

defensin

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48

what is the process of differentiating blood cells?

hematopoiesis

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49

true or false: myeloid progenitors give rise to all blood cell types?

false

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50

which is not an effect of interferon signaling?

NOT B cell infiltration; IS blocking translation, mRNA destruction, apoptosis

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51

what complement protein is a positive regulator of the pathway?

CFB

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52

A ___ of a diseases would include pus, rash, and swelling.

sign

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53

if a staphylococcus aureus strain causes death faster than another strain, it has higher what?

virulence

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54

what category of infection has a quick onset of symptoms and ultimately ends with loss of the virus from the host?

acute

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55

what category of infection persists with flare-ups of symptoms periodically?

latent

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56

what category of infection may have symptoms or not but continuously produces virus for the duration of life?

chronic

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57

HIV is what category of infection?

latent

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58

which cells recognize MHC Class I molecules?

TC_subscript cells

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59

the first immunoglobulin produced in a primary immune response is what?

IgM

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60

what cell type bears CD4 receptors?

TH_subscript cells

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61

what cell type bears CD8 receptors?

TC_subscript cells

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62

true or false: mutations in immunoglobulin genes are beneficial

true

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63

lymphocytes are directly involved in what?

adaptive immunity

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64

what immunoglobulin is present the least in serum?

IgE

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65

which is “not“ an inflammation of the nervous system?

NOT colitis; IS meningitis, encephalitis

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66

what cytokines induce fever?

pyrogens

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67

which genus doesn’t hide within a host cell for protection?

bacillus

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68

some clostridium species that act as pathogens release botulinum and tetanospasmin toxins that cause what?

none of the above (dysentery, enhanced neurotransmitter release, kidney disease)

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69

what toxin induces membrane pore formation killing the host cell?

both of the above (leukocidin & streptolysin)

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70

what type of cell is tasked with killing a virally-infected host cell lacking MHCs on its surface

NK cells

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71

true or false: macrophages can shift between activated forms

true

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72

which genus of bacteria is a normal skin resident?

staphylococcus

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73

B cells, macrophages, and erythrocytes are all differentiated from what?

hematopoietic stem cells

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74

which is not a granulocyte?

NOT lymphophil; IS eosinophil, basophil, neutrophil

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75

which is not a characteristic of an antibody?

NOT intermediate chain; IS light chain, heavy chain,

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76

the effector form of a B cell is what?

plasma cell

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77

TLRs are an example of what?

pattern recognition receptor

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78

programmed cell death that avoids inflammation is what?

apoptosis

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79

the process of a leukocyte passing out of the blood vessel to the tissue is what?

diapedesis

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80

an infected cut is what category?

acute

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