varicella zoster viral infection is what category of infection?
latent
during the NETosis, neutrophils expel what to trap pathogens?
DNA
which is “not” a benefit of our microbiome?
NOT more efficient use of ATP; IS better digestion, vitamine production, more efficient use of ATP
these cells will cause allergic reactions in some individuals
mast cells
the compound released by (mast cells) is a derivative of what amino acid?
histidine
what protein makes skin repel water?
keratin
when cells fuse to form one large multinucleated cell, it is called a ___?
syncytium
Infants lack the ability to defend against what even using standard vaccination?
T-independent antigens
Virally infect cells can sometimes use fake versions of what to elude the immune system?
MHCs
Which bacterial genus occupies the normal gut microbiome?
all of the above (clostridium, lactobacillus, bactericides)
which cytokine is anti-inflammatory?
IL-10
true or false: lactobacillus increases the pH of the vagina to block pathogen growth
false
which is *not* composed of a mucous membrane?
NOT the skin; IS esophagus, sinuses, eye
what organelle is used for movement of phlegm?
the cilium
which type of receptor is composed of a constant and variable region?
both of the above (T cell receptor & B cell receptor)
true or false: inflammation is always caused by a pathogen
false
which is “not” a component of the MAC?
NOT C5a; IS C6, C7, C9
TLRs in endosomal lumen membranes detect what?
dsRNA
Lectin receptors for pathogens often detect what monosaccharide component of a polysaccharide?
mannose
this inflammasome is formed upon activation of what?
NOD-like receptors
the interferon signaling cascade is most associated with what kind of infection?
viral
which is “not” a mechanism for a bacterium to escape phagocytosis?
NOT destroying the lysosome; IS cleaving complement proteins, mimicking host cells, embedding Fc receptors in membrane
which yeast is pathogenic to immunocompromised individuals?
candida albicans
which cytokine induces apoptosis in neighboring cells?
TNFalpha
which is a proinflammatory cytokine?
all of the above (TNFalpha, IL-6, IL-1)
which is “not” a type of PRR?
NOT LAMP; IS MAMP, DAMP, NLRP
which is “not” a form of activated macrophage?
M3
giant cells are formed by fusion of what?
macrophages
which is a form of inflammatory mediator?
prostaglandin
during inflammation, blood vessels __ ?
dilate
chronic inflammation can be induced by what?
all of the above (obesity, cancer, autoimmunity)
the presence of bacteria in the blood stream is called what?
bacteremia
effector proteins from a bacterium are injected through what system?
type III secretion system
bacteria use what protein type to attach before colonization?
adhesins
using the host cell’s actin cytoskeleton to induce endocytosis is called membrane ____?
ruffling
the order or infectious disease progression begins with ___ and ends with __.
none of the above (CORRECT: incubation; convalescence)
which immunoglobulin adheres to mucous membranes through secretion?
IgA
which complement protein is an opsonin?
C3b
which leukocyte is the first on the scene for an infection?
neutrophil
what is not a sign of the inflammation?
NOT bruising; IS redness, swelling, pain
what do antibodies recognize?
both of the above (epitopes & antigens)
B cells and T cells gather in clusters in the ___ of a lymphatic organ.
germinal center
which is a form of antigen presenting cell?
all of the above (B cell, macrophage, dendritic cell)
true or false: central tolerance occurs in the spleen
false
what kind of pathogen uses the answer to the above question to evade the immune system?
virus
this protein is used to sequester iron away from microbes:
lactoferrin
which is an antimicrobial peptide produced by our cells?
defensin
what is the process of differentiating blood cells?
hematopoiesis
true or false: myeloid progenitors give rise to all blood cell types?
false
which is not an effect of interferon signaling?
NOT B cell infiltration; IS blocking translation, mRNA destruction, apoptosis
what complement protein is a positive regulator of the pathway?
CFB
A ___ of a diseases would include pus, rash, and swelling.
sign
if a staphylococcus aureus strain causes death faster than another strain, it has higher what?
virulence
what category of infection has a quick onset of symptoms and ultimately ends with loss of the virus from the host?
acute
what category of infection persists with flare-ups of symptoms periodically?
latent
what category of infection may have symptoms or not but continuously produces virus for the duration of life?
chronic
HIV is what category of infection?
latent
which cells recognize MHC Class I molecules?
TC_subscript cells
the first immunoglobulin produced in a primary immune response is what?
IgM
what cell type bears CD4 receptors?
TH_subscript cells
what cell type bears CD8 receptors?
TC_subscript cells
true or false: mutations in immunoglobulin genes are beneficial
true
lymphocytes are directly involved in what?
adaptive immunity
what immunoglobulin is present the least in serum?
IgE
which is “not“ an inflammation of the nervous system?
NOT colitis; IS meningitis, encephalitis
what cytokines induce fever?
pyrogens
which genus doesn’t hide within a host cell for protection?
bacillus
some clostridium species that act as pathogens release botulinum and tetanospasmin toxins that cause what?
none of the above (dysentery, enhanced neurotransmitter release, kidney disease)
what toxin induces membrane pore formation killing the host cell?
both of the above (leukocidin & streptolysin)
what type of cell is tasked with killing a virally-infected host cell lacking MHCs on its surface
NK cells
true or false: macrophages can shift between activated forms
true
which genus of bacteria is a normal skin resident?
staphylococcus
B cells, macrophages, and erythrocytes are all differentiated from what?
hematopoietic stem cells
which is not a granulocyte?
NOT lymphophil; IS eosinophil, basophil, neutrophil
which is not a characteristic of an antibody?
NOT intermediate chain; IS light chain, heavy chain,
the effector form of a B cell is what?
plasma cell
TLRs are an example of what?
pattern recognition receptor
programmed cell death that avoids inflammation is what?
apoptosis
the process of a leukocyte passing out of the blood vessel to the tissue is what?
diapedesis
an infected cut is what category?
acute