What are the different types of asexual reproduction?
Binary fission, Budding, Fragmentation, Parthenogenesis, Regeneration
Binary fission
Single parent cell doubles its DNA, then divides into two cells, EX: bacteria
Budding
Small growth on surface of parent breaks off, resulting in the formation of two individuals, EX: yeast and some animals
Fragmentation
Organisms break into two or more fragments that develop into a new individual, EX: many plants, as well as some animals (like coral, sponges, and starfish)
Parthenogenesis
An embryo develops from an unfertilized cell, EX: invertebrates, as well as in some fish, amphibians, and reptiles
Regeneration
the renewal, regrowth or restoration of a body part
How is DNA packed into chromosomes?
The DNA wraps around Histone like a spool and thread, when the cell prepares to divide the chromatin starters to condense and forms a chromosome
What are the main differences between mitosis and meiosis?
MEIOSIS : during prophase the chromosomes coil up and find their homologous pairs which then proceed to cross over, gamete (sex cells) are dividing, each new cell gets ½ of the genetic information, cells divide twice and replicate once, haploids, more steps (prophase 2, metaphase 2, anaphase 2, telophase 2, cytokinesis)
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MITOSIS : somatic (body cells) are dividing, creates exact copies of the cell, cells divide once and replicate once, Diploids
Where do traits have to be located to be passed onto offspring?
Traits need to be located on the genes in sperm and eggs in order to be passed down to offsprings.
What is the principle of segregation?
Each individual has two allele for a gene, the alleles of each gene segregate during meiosis
What is the principle of independent assortment?
When genes separate and are places within the gametes distribution is random, cannot predict with 100% accuracy
What types of cells go through meiosis? Mitosis?
Gametes, or sex cells, go through meiosis and Stomatic, or body cells, go through mitosis
What important event happens in interphase I? Prophase I? MetaphaseI?
In interphase 1 the sex cells live out their normal lives and replicate their DNA. In prophase 1 the chromatin condense into chromosomes and the homologous chromosomes attach with each other and switch part of their DNA in a process called CROSSING OVER. In metaphase one the homologous sets of chromosomes line up on the metaphase plate (the sets not individual chromosomes) and spindle fibers appear.
What kind of cells are haploid? Diploid?
Haploid cells are gametes and diploid cells are stomatic
How are male and female meiosis different?
Female meiosis produces the female gametes or the ova (eggs) and male meiosis produces the male gametes or sperm. In male meiosis both stages of meiosis are completed and you end up with 4 sperm cells, male meiosis also happens basically their entire life after puberty. In female meiosis, after both stages of meiosis are completed there is only 1 ovum (egg) all the nutrients are passed to that one egg and the other cells are called POLAR BODIES which will eventually disintegrate. Female meiosis only occurs in the embryonic stages of women, once females are born they have all the eggs they will have for the rest of their life.
What are the sources of genetic variation?
CROSSING OVER during prophase 1 in meiosis, mutations, and environmental stimuli are all responsible for genetic variation
Why aren’t all gametes from an individual the same?
All gametes from an individual aren’t the same because of the law of independent assortment which states that when genes seperarate and are placed within the gametes distribution is random. In other words, gametes contain only half of the genetic makeup of a person and that certain half is different in every gamete.
What separates during anaphase I? Anaphase II?
During anaphase 1 the homologous chromosome sets split. During anaphase 2 the chromatid split apart at the centromere.
Chromatin
long fibers and histones of DNA that eventually form chromosomes
Chromosome
the condensed chromatin (DNA) that goes through meiosis and mitosis and is visible through a microscope
Homologous chromosome
the same chromosomes from each of your parents that pair up, pair based on their size, shapes, and whats on that trait (hair color, skin pigment), have copies of the same genes, autosomes
Sister chromatid
the identical copies (chromatids) formed by the DNA replication of a chromosome which are attached by the centromere
Gametes
sex cells, sperm in men, eggs in female, they use meiosis
Diploid
2n (n=number of sets), cells that have 2 complete homologous chromosomes of each set, EX: human diploid number is 46, occurs in stomatic cells
Haploid
1n (n=number of sets), cells that have 1 chromosome for each set, EX: humans haploid number is 23, occurs in gametes (sperm and egg)
How do genes, alleles, and chromosomes relate?
Chromosomes are condensed versions of DNA in an organism. Genes are sections of DNA that provide instructions for a character (hitch hiker’s thumb). Alleles are different forms of a gene (H = straight thumb h = hitch hickers thumb)
Who was Gregor Mendel and what was he known for?
Gregor Mendel fathered genetics, published an experiment in 1865 which experimented with pea plants and was focused on genetics and traits.
What is a parental cross?
Parental cross refers to the first set of parents crossed. The parents' genotype would be used as the basis for predicting the genotype of their offspring (F1 generation)
What are the genotype and phenotype ratios for the following generations (filial levels) from a true parental cross?
F1
genotype - 1:2:1
phenotype - 3:1
F2
genotype - 1:2:1
phenotype - 3:1
What do Punnett squares allow us to do?
Punnett squares help us to predict the variations and probabilities that can come from cross breeding.
What is the order for genotype and phenotype ratios for a monohybrid cross?
genotype - HD : HE : HR
phenotype - D : R
What is the order of phenotype ratios for a dihybrid cross?
D/D : D/R : R/D : R/R
What would it be for a cross between two individuals that are heterozygous for both traits?
9 : 3 : 3 : 1
Dominant
The trait that has a higher probability of occurring and more likely to been seen (capital letter)
Recessive
The trait that has a lower probability of occurring and less likely to be seen (lowercase letter)
Homozygous
alike genetic pairs also called purebred (EX : TT or tt)
heterozygous
one of each allele version (EX : Tt)
Gene
a section of DNA that provides instructions for a character (EX : hitchhiker's thumb)
Allele
different forms of a gene (EX : H=straight thumb h=hitchhikers thumb)
there are always 2 alleles, two copies of each homologous chromosomes, each carry one allele
Locus
the location of the gene on a chromosome
Heredity
the transfer of genetic characters from parents to offsprings by the process of fertilization (EX : two blue eyed parents will always give birth to a blue eyed baby)
Genotype
all possible allele combinations of the offspring produced (EX: heterozygous)
Phenotype
physical characteristics of each genotype (EX: can roll your tongue)
Carrier
An individual who carries one harmful allele for an autosomal recessive disorder is known as a carrier. Carriers are heterozygous because they have two alleles of a gene.
How do you write genotypes for an X-linked trait?
When writing genotypes for an X linked trait you put the dominant/recessive allele on the X chromosomes (EX: XBXB or XbY)
Can a male be a carrier for an X-linked recessive trait?
No, since males only have one x chromosome they can only have the recessive trait or have the dominant trait, they cannot be carriers.
What individuals are X-linked traits more common in? Why?
X-linked traits are more common in men because for men to possess this recessive trait they would need to inherit one recessive trait from their mother so she would either have to have that trait or be a carrier. But in order for a female to possess that recessive trait she would have to inherit one recessive trait from both her mother and father meaning her father would have to have that trait and her mother out also have to have it or carry it.
Codominant (Description, What does the heterozygote look like?, How do you write the genotype)
Description - traits that have more than 2 allele versions, if both alleles are dominant, individual shows both traits, if individual has 1 dominant and 1 recessive the dominant will mask
What does the heterozygote look like? - the heterozygote will show the dominant trait (unless it is a mix between two different dominant trains, then both traits would be shown)
How do you write the genotype - In the case of blood type you would write the genotypes like this IA IB i
incomplete dominance
Description - Allele versions do not mask each other so heterozygotes appear to be a mix of the 2 alleles
What does the heterozygote look like? - the heterozygote will appear to be a mix of the two alleles
How do you write the genotype - you would write the genotype as either a normal dominant trait or a dominant trait with a prime symbol (EX: F or F’)
Describe how the inheritance pattern of multiple alleles works (review the rabbit coat type example).
With the inheritance pattern of multiple alleles offsprings are able to have traits that neither of their parents possess. They are also able to show multiple traits at once instead of those traits mixing or one masking the other.
What is epistasis?
a circumstance where the expression of one gene is modified (e.g., masked, inhibited or suppressed) by the expression of one or more other genes. ( An example of epistasis is the interaction between hair color and baldness. A gene for total baldness would be epistatic to one for blond hair or red hair)
What are the genotypes that give each blood type?
AB - IAIB
B - IBIB IBi
O - ii
A - IAIA IAi
What are the three inheritance patterns that blood type involves?
Blood types can either have A protein, B protein, or no protein. They can either have type O blood, type A or B blood, or type AB blood (codominance)
Is genetics the only factor that determines traits?
No, traits can also be determined by environmental factors
What sex chromosome do males give to their daughters? Sons?
Males give an X to their daughters and a Y to their son.
Does the mother or father determine the biological sex of the child?
The father determines the biological sex of the child
Shaded individuals correspond to what on a pedigree?
Shaded individuals have the trait that the pedigree is talking about.
How do you indicate a carrier on a pedigree?
XBXb
What inheritance patterns can have carriers?
X-linked inheritance
If you see more males affected on a pedigree what inheritance pattern do you assume?
You assume it's an x-linked trait
What inheritance pattern do you assume if equal or more females are affected?
You assume it's an autosomal trait
If the inheritance pattern skips a generation what inheritance pattern is assumed?
Autosomal recessive inheritance pattern is assumed
What genotype do you fill in first if you determine it to be autosomal dominant? Autosomal recessive?
If you determine it to be autosomal dominant you will fill in all of the unshaded shapes with the recessive genotype. If you determine it to be autosomal recessive you will fill in all of the shaded shapes as the recessive genotype.
What information can you gain from a karyotype?
When looking at a karyotype you can tell if there are any chromosomal abnormalities. Seeing if you have too many or not enough chromosomes can cause serious health issues
What happens during nondisjunction?
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate properly during cell division
What kind of disorders does Nondisjunction create?
Nondisjunction can create trisomy genetic disorders like Down's syndrome (trisomy of chromosome 21), Patau's Syndrome (trisomy of chromosome 13), Edward's Syndrome (trisomy of chromosome 18) and Turner's Syndrome (the presence of only one X chromosome)
What is the difference between Klinefelters and Turner’s syndrome?
Klinefelter's syndrome occurs when a male has an extra x chromosome, this male may be sterile, have some breast development, and have mild intellectual disabilities. Turner’s syndrome occurs when a male has no Y chromosome he just has an X, this male may be under 5 feet tall, have a webbed neck, a broad “shield like” chest, may be sterile, and may show mild intellectual disabilities.
What is the human diploid number?
The human diploid number is 46
Autosomes
all chromosomes that determine traits and characteristics, 44 autosomes (pairs 1-22)
Sex chromosomes
chromosomes that determine the sex of offspring, 2 sex chromosomes (pair 23)
Karyotype
an individual's complete set of chromosomes.
Monohybrid Crosses - B= black fur b= white fur
Cross an individual who has homozygous black fur with an individual who has white fur.
Dihybrid Crosses - B= Black fur b= white fur E= black eyes e= red eyes
Cross a mouse who is heterozygous black furred, red eyed with an individual who is heterozygous black furred and heterozygous black eyed.
X-linked Crosses - b= Balding B= normal hair Remember to make the b’s superscripts on X
Cross a female carrier with a male who is balding
Codominant and Multiple Allele - Blood typing
Cross an individual who is heterozygous type B with an individual who is AB
Incomplete: H= red H’= blue
Cross a red individual and a purple individual
What are the phases of meiosis?
interphase, prophase 1, metaphase 1, anaphase 1, telophase 1, cytokinesis, prophase 2, metaphase 2, anaphase 2, telophase 2, cytokinesis
What is genetics?
the study of heredity
What are the two types of inherited traits?
species traits (where you head and organs are) and individual traits (hair and eye color)
What is probability?
number of favorable chances / number of total possibilities
EX: 1/52 chance you will pull a 5 of hearts out of a deck of cards
What is a pedigree?
a family tree that allows someone to track a trait through generations
What do the symbols on pedigrees mean?
a blank square means male and a filled in square means a male that has the trait
a blank circle means female and a filled in circle means a female that has the trait
How to do an x-linked pedigree
make sure pedigree is supposed to be x-linked (either says or has more males with the trait than females)
label all individuals xx or xy
label all males X’s
label the first X on females (unless recessive)
look up/down generations to label 2nd X on females
How to do an autosomal pedigree
make sure pedigree is supposed to be autosomal (same about of females and males have the trait or it says it is autosomal
trait D/R
non shaded (recessive)
label 1st allele
look up and down to label 2nd allele