Biotech basics, history of biotech based on crash courses #40-#44, lab safety symbols, and NFPA diamonds
biotechnology
the study and manipulation of living things OR their component molecules, cells, tissues, organs, etc. to benefit human beings
DNA fingerprinting
identifying the pattern of certain sequences in parts of DNA
blue diamond
health hazard
red diamond
fire hazard
white diamond
specific harzard
yellow diamond
reactivity hazard
flammable
oxidizing
corrosive
explosive
general warning/harmful
toxic
gas
health hazard
environment
chromosomes
nucleus contained thread-shaped structures
cell division
chromosomes played a critical role in this
Linus Pauling
characterized the alpha helix structure of common proteins
alpha helix
the structure of common proteins characterized by Linus Pauling
James Watson and Francis Crick
what two scientists figured out DNA was a double helix?
DNA
a machine language to make RNA, which became an assembly-language “program”
Stanley Miller and Harold Urey
chemist and his advisor that produced amino acids
amino acids
building blocks of life
recombinant DNA (rDNA)
cloning sections of one organism’s DNA to another
Diamond v. Chakrabarty
supreme court case that determined whether or not a company can patent a bioengineered life form; ruled in favor of respondent that it is legal
chlorpromazine/thorazine
first blockbuster brain drug approved for psychiatric use; an anti-psychotic
tranquilizers
first scientifically created, advertising-promoted drug for the “worried-well”
valium
“mother’s little helpers”; many women took it due to the depression and anxiety may suffered from due to the loneliness and limitations the role of “housewife” that women had to follow back then
chemical imbalance theory
theory that depression may be caused by elevating and lack of norepinephrine and serotonin
cells grow indefinitely
what happens when one turns certain samples of human tissues into immortalized cell lines using tissue engineering?
HeLa
most important cell line in biomedical research; particularly loaded technology; used to clone cells, revolutionized medicine, but the patient’s cell that was used never gave consent or received compensation
genetically modified organism (GMO)
had its genome, or DNA blueprint, edited to include genes from another organism
grains
big money GMOs, which first faced little pushback from consumers
in-vitro fertilization
isolating gametes, or sex sells, and moving them around in labs
somatic cell nuclear transfer (SCNT)
cloning
sanger sequencing
chopping up DNA, tagging them to florescent dyes, and sorting out sequences by length
Kary Mullis
developer of PCR
polymerase chain reaction
developed by Kary Mullis; an automated way of taking advantage of natural processes for copying DNA
Human Genome Project
began October 1st, 1990 & competed in 2003; had the goal of sequencing a representative “working draft” of 90% of a human genome—a model blueprint for the human body
shotgun sequencing (shotgunning a genome)
fragmenting genome into bits in a row, then letting computers piece it back together to make the sequence
BIll Clinton
who signed an executive order in 2000 to prevent genetic discrimination in federal workplaces
DIY bio
movement where amateurs can sequence DNA and do bioengineering at home
Human Genome Diversity Project
collect DNA samples from thousands of people to understand human diversity
Moore’s Law
the # of electronic switches that people could squeeze onto one computer chip would double
Steve Jobs and Steve Wozniak
two engineers committed to computing for play, not just always work
Microsoft
founded by Bill Gates in 1975
Defense Advanced Research Projects Agency (DARPA)
to protect citizens from soviet attacks if power lines were out or to pass information quickly
pack-switching
used by ARPANET to send data in small, independent, broken-up parts that can each find their own fastest routes and be reassembled later
Sir Tim Berners-Lee
invented world wide web in 1990; built the first web browser
block chain
list of time-stamped records which are linked using cryptography and resistant to fraud
cryptocurrency
kinds of money not backed by sovereign nations but by groups of co-invested strangers on the internet (ex: NFTs)
biosociality
associating with each other based on shared molecules
genetic therapies
replacing regions of DNA to give a rise to disease with doctor-designed therapeutic gene; genes get taken out, changed, and out back un
personalized medicine
each patient will have care tailored to each individual genome
transcriptomics
how regions of DNA are copied into little strands of DNA
proteomics
how proteins fold together
metabolomics
how energy moves around inside and out of cells
CRISPR
most efficient way of gene-edting; when a virus enters the microbe’s cell, it is recognized as being on the list and an associated protein cuts up the virus; it reads for specific DNA sequences and only cuts these; instead of a step-by-step process it enables a whole solution to be programmed all at once
reprogenetics
engineering babies
microbiomics
genomics of microbes
synpases
collection of neurons joined by little gaps called ______.
connectome
dream database for many researchers; a total map of how neurons are linked
zip code
better predictor of health than a genetic code