BIOCHEM PART 6 (pentose phosphate pathway)

Pentose Phosphate Pathway Products

Pentose Phosphate Pathway is also known as

the enzyme that helps to catalyze:

Glucose-6-phosphate —> 6- phosphogluconolactone

the enzyme that helps to catalyze:

6- phosphogluconolactone —> 6-phosphogluconate

the enzyme that helps to catalyze:

6-phosphogluconate —> ribulose 5 -phosphate

Final product of oxidative stage of pentose phosphate pathway

the enzyme that helps to catalyze:

Ribulose-5-phosphate —> Ribose-5-phosphate

it is needed for the synthesis of RNA

the enzyme that helps to catalyze:

Ribulose-5-phosphate —> xylulose-5-phosphate

the enzyme that helps to condense:

xylulose-5-phosphate + Erythrose-4-phosphate —> glyceraldehyde -3- phosphate & Fructose 6- phosphate

the enzyme that helps to condense

Ribose-5-phosphate + xylulose-5-phosphate —>Sedoheptulose-7-phosphate & glyceraldehyde-3- phosphate

the enzyme that helps to catalyze

Sedoheptulose-7-phosphate —>Erythrose-4-phosphate

the enzyme that helps to catalyze:

glyceraldehyde-3- phosphate —> fructose 6 phosphate

TRUE OR FALSE

if Ribose-5-phosphate can’t undergo RNA synthesis, it will condense with Xylulose-5-P to create other subtrates.

Main function is to RECYCLE PRODUCTS

it is important IN THE SYNTHESIS OF FATTY ACIDS and to keep our master antioxidant glutathione reduced

The three amino acids in Glutathione

Tripeptide with a free -SH group (thus the abbreviation, GSH)

TRUE OR FALSE

Reduced Glutathione helps in deactivating PEROXIDES, which can cause cellular damage.

When oxidized in detoxification of free radicals such as peroxides, the product is a dimeric form of the peptide, held together by a __

• Deficiency of Glucose-6-P dehydrogenase causes a reduced level of available NADPH

• premature death of RBCs

• Denaturation and aggregation of hemoglobin leads to this type of anemia

Lower levels of NADPH lead to ___

__ group in hemoglobin is destabilized and causes it to denature and aggregate

antioxidant of RBC

Hemolytic anemia is worsened by the intake of drugs and food that are converted to peroxides, such as _____________(and other Quinine Derivatives) and __________ Beans

• Prevent the accumulation of LACTIC ACID/lactate

• Regenerate NAD for ATP synthesis

Cori Cycle maintains adequate supply of ____________for tissues that cannot perform gluconeogenesis (such as the brain)

TRUE OR FALSE

in case of vigorous activities, Pyruvate is converted to Lactate

Too much Lactate in Muscle can cause

Glutathione’s reducing agent