Histology
The study of body tissues
Epithelial
Connective
Muscle
Nerve
What are the 4 major human body tissues?
Epithelial
What does this describe?
Cover all body surfaces
Line all body cavities and hollow organs (heart)
Are the major tissues of glands
Connective
What does this describe?
Bind structures together
Form a framework for organs and the body as a whole (bones)
Store fat, transports substances, protects against disease, help repair tissue damage
Muscle
Composed of cells that have the ability to shorten or contract
Nerve
Transmits impulses (messages) throughout the body
Embryology
The study of the development of the fertilized egg and its differentiation into tissues and organs
Zygote
The first cell of a new individual
Fertilization
Union of special reproductive cells called sperm and egg
Sperm
Make gamete (reproductive cell); contains the haploid number of chromosomes… 23
Egg (ovum)
Female gamete; contains the haploid number of chromosomes… 23
46
What is the diploid number of chromosomes the zygote contains after fertilization?
Mitosis
The duplication and division of the cell nucleus; cell passes on cell info.
Prophase
Metaphase
Anaphase
Telophase
What are the 4 phases of mitosis?
Cytokinesis
The cell division of the cytoplasm
Interphase
What phase does this describe?
Time between cell division
Cell is not resting
Cell grows
Performs its physiological activities
DNA replication begins near end
Prophase
What phase does this describe?
Nuclear membrane disappears
Cytoskeleton elements begin to disassemble
Chromosomes become visible
Centrioles move to opposite poles
Asters form centrioles + astral rays (microtubules)
Astral rays extend to form spindle fibers
Duplicated chromosomes shorten and thicken; each half = chromatid
Metaphase
What phase does this describe?
Chromosomes migrate to equator of the cell
Accomplished by spindle fiber lengthening/shortening
Ends when centrosomes divide
Kinetochore will attach to spindle fibers
Anaphase
What phase does this describe?
Individual chromosomes (formerly chromatids) separate from each other and move apart toward opposite poles
Ends when chromosomes reach the poles
Anaphase A
Chromosomes move away from the equatorial plate toward the poles
Accomplished by spindle fibers shortening
Anaphase B
Polar microtubules push against each other; thus, pushing centrioles apart
Telophase
What phase does this describe?
Chromosomes have reached the poles and begun to decondense
New nuclear membrane begins to form around each set of chromosomes
Kinetochore microtubules dissolve
Polar microtubules continue to elongate
Cytokinesis
What does this describe?
Division of the cell’s cytoplasm
Process where the cell divides into 2
Cleavage furrow is first sign
Actin filaments form a contractile ring
Ring contracts until cell pinches off forming 2 daughter cells
Cleavage furrow
Sight of plasma membrane invagination
Usually appears near end of anaphase
Embryology
The study of the development of the fertilized egg and its differentiation into tissues and organs
Embryo
An individual in its earliest stages of development
Humans: from implantation to 8th week of pregnancy
Fetus
From 8th week to birth
Embryogenesis
The development of the embryo
Zygote
Morula
Blastula
Gastrula
What are the 4 stages of development?
Zygote
First cell in new individual
Result of conception/fertilization
Contains the genetic information (DNA) to become a child
1 cell
Morula
Solid ball of cells (16-64 cells; no bigger than zygote)
Result of repeated cell division of the zygote
Blastocyst (blastula)
Hollow ball of cells
Results when cells center of morula bind tightly together to form a compact sphere
Trophoblast
Outer layers of cells that will eventually become the placenta
Apart of blastula
Embryoblast
Inner cell mass
70-100 cells
Eventually becomes the embryo
Apart of blastula
Gastrula
Developmental stage in which embryoblast is reorganized into three layers of germ cells
Ectoderm, mesoderm , endoderm
Ectoderm
Outside layer; surrounds the other layers
Mesoderm
Middle layer
Endoderm
Inside layer; lies at the most interior of the embryo
differentiation
the process whereby an undifferentiated embryonic cell acquires the features of a specialized cell such as heart, liver or muscle cell; transformation of cells into tissues
epithelial
connective
muscle
nerve
What 4 major body tissues do the primary germs layers, ectoderm, mesoderm, and endoderm, give rise to?
stem cells
human embryonic stem cells are undifferentiated cells that can develop into any of the specialized cell types found in the human body
totipotent
can develop into all cell types (zygote/morula); type of stem cell
pleuripotent
can develop into all cell types except embryonic membranes- give rise to the 3 primary germ layers; type of stem cell
multipotent
can develop into a limited number of cell types (hematopoietic (any type of blood) stem cells)
ectoderm
What primary germ cell is apart of…
epidermis of skin and its derivates
cornea and lens of eye
adrenal medulla
tooth enamel
epithelium of pineal and pituitary glands
nervous system
sensory receptors in epidermis
mesoderm
What primary germ cell is apart of…
notochord
skeletal system
muscular system
muscular of stomach and intestines
excretory system
circulatory and lymphatic system ( except germ cells)
dermis of skin
lining of body cavity
adrenal cortex
endoderm
What primary germ cell is apart of…
epithelial lining of digestive tract
epithelial lining of respiratory system
lining of urethra, urinary bladder, and reproductive system
liver
pancreas
thymus
thyroid and parathyroid glands
epithelial tissues
What do these functions describe?
protect exposed portions of the body’s organs and safeguard them from abrasion and injury
control the passage of materials from the outside environment to specialized body cells below
found at the surface of the body organs
avascular
have no blood vessels of their own
reproduce a high rate; two surfaces
composed of layers (strata) of cells
named accordingly to cell shape and arrangement
apical
free surface
basal
bound surface
simple
single layer of cells
stratified
multiple cell layers
Squamous
extremely thin and irregular shape
have appearance of fish scales
Cuboidal
Cube shaped like dice
Columnar
Shaped like columns
Longer than they are wide
Basal lamina
Meshwork of fine protein filaments and protein fibers on which the tissues sits
Produce by the epithelial cells
Junctional complex
Intercellular connections
3 types- tight, desmosomes, gap