Gram negative cocci

Neisseria

Moraxella

Kingella

Oligella

Acinetobacter

Neisseria Meningitidis (Meningococcus)

Neisseria Gonorrhoeae (Gonococcus)

Others:N.lactamica, N.mucosa, N.Polysacchareae, N.subflava, N.sicca

Kidney/bean shaped diplococci

Non motile

Non sporing

Enriched medium

35-37 degree Celsius

Typical G- cell wall

Capsule and pili may be present

Respiratory tract

Genital tract

Pyogenic , meningitis and meningococcemia , Penicillin G

Pyogenic

local (Gonorrhoeae- urethritis/cervicitis) - ceftriaxone plus doxycycline(chlamydia trachomatis coinfection)

Ascending (pelvic inflammatory disease) - cefoxitin plus doxycycline

Disseminated (Disseminated gonococcal infection) - ceftriaxone

Neonatal (conjunctivitis/ophthalmia neonatorum) - ceftriaxone with silver nitrate or erythromycin for prevention

PCR are used for serotyping

Serotyping is based of the antigenic variation of capsular polysaccharide

Common:A,B,C,W-135,Y

Others: DHIK,L,29E,X,Z

(Serogroup - slide agglutination)

Polysaccharide capsule :resists phagocytosis by PMNs

Endotoxin(LPS): fever , shock and o

Immunoglobulin A protease

Neisseria

Meningococcemia

CSF Glucose:

Purulent urethral discharge caused by Neisseria Gonorrhoeae

Neonatal conjunctivitis(ophthalmia neonatorum ).

Purulent exudate on lower right eyelid(chlamydia trachomatis)

Neisseria Gonorrhoeae gram stain

Bean shaped gram negative diplococci within a neutrophil

1. Genital Gonorrhoeae

2. Abscess of the Bartholins and Skenes glands

3. Proctitis (renal inflammation):symptomatic in homosexual males

3. PIDs :

Salipingitis,pelvic peritonitis, ectopic pregnancy, infertility

4. Fitz Hugh Curtis syndrome

5. Pharyngitis

6. GADS- gono arthritis dermatitis syndrome

7. Disseminated gonococcal infection (DGI).

   arthritis,meningitis,endocarditis

8. Vulvovaginitis in girls

9. Conjunctivitis (ophthalmia neonatorum)