Chapter 9: Kinds of Research

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LIS1

A gene that helps to tell the brain how to grow.

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Arvid Carlsson

________ discovered that Parkinsons was caused by the depletion of dopamine using rabbits & mice.

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Next-generation sequencing

________ is expected to uncover the function & sequence of all 20, 000+ genes (exome).

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Electroencephalogram

________ (EEG): electrodes are placed on the head and record the electrical activity of the brain in response to a variety of stimuli and activities.

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Tracers

________ break down at a slower rate and do not require a nearby particle accelerator.

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Sea Slugs

________ were important for studying learning and memory.

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MRIs

________ reveal the precise extent of tumors fast and vividly.

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Deletion

________ of a portion of chromosome 16 can lead to many neurological symptoms.

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Event

________- related optical signal: records how light scatters in response to fast cellular changes that arise when neurons fire.

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Mice

________ are being used to understand what factors change after a certain age to prevent rewiring.

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Eric Kandel

________ did work on learning and memory.

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FMRI

________: gene that is abnormal in those with fragile X syndrome.

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RBI

________: gene that causes retinoblastoma.

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Magnetoencephalography

________ (MEG): reveals the source of weak magnetic fields emitted by neurons.

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MEG

________ can characterize changing patterns of neural activity down to milliseconds.

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maps of brain

Staining techniques helped scientists look at pathways and connections to make road ________ connections.

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Zebrafish

________ have transparent fertilized eggs, so they are good models for developmental neuroscience research.

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Magnetic Resonance Spectroscopy

________ (MRS)- uses the same machinery as an MRI but measures the concentration of specific chemicals in different parts of brain.

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Electrodes

________ are placed on the head.

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radioisotope

The ________ shows up in the brain in proportion to how hard local neurons are working.

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animal species

Many vertebrate ________ are genetically and biochemically similar to humans.

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Optical imaging

________: relies on shining weak lasers through the skull to see brain activity.

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Drugs

________ can affect brain systems concerned with learning and memory.

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Electrophysiology

________- the study of electrical properties of neurons.

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ventral tegmental area

The ________ communicates with the nucleus accumbens (an area next to the bottom of the midbrain).

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Fruit flies

________ have a less complex nervous system, but they and humans share many features.

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Rabbits

________ and cats were very important models for studying vision and other senses.

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Kabuki syndrome

A rare, multi-system syndrome that is characterized by many different abnormalities including skeletal abnormalities, short stature, and varying levels of intellectual disability.

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Tuberous sclerosis complex

________: a genetic disorder characterized by the growth of many benign tumors in the body.

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Functional Magnetic Resonance Imaging

________ (fMRI): compares brain activity under resting and active conditions.

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Amblyopia

________: the vision of one eye is greatly reduced because the eyes do not work well together.

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DMD

________: gene thatcauses Duchenne muscular dystrophy.

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Invertebrates

________ were also used to learn more about the human nervous system.

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Genes

________: sections of DNA that code for a product.

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Transcranial

________ magnetic stimulation (TMS): induces electrical impulses in brain by altering magnetic fields through an electromagnetic coil held against the scalp that emits powerful magnetic pulses.

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discovery of chemicals

After the ________ transported within neurons, methods have been developed to visualize brain activity and precisely track nerve fiber connections within an animals nervous system.

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DNA strands

________ are long, spiraling, double helixes arranged in 46 chromosomes.

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Positron Emission Tomography

________ (PET)- a scanning technique based on the detection of radioactivity emitted when positrons undergo radioactive decay in the brain.

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PET

________ allows scientists to measure the changes in the release of some neurotransmitters.

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Diffusion Tensor Imaging

________: takes advantage of diffusion rates of water and shows connections in the brain.

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Magnetic Resonance Imaging

________ (MRI)- a non- invasive scanning technique that provides a high- quality 3D image of organs and structures.

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Diffuse optical tomography

________: used to create brain activity maps.

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TMS

Information from ________ and fMRI can show the correlation between a brain region and behavior.

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Levodopa

________: a drug that gets converted to dopamine in the brain.

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PET studies

________ helped scientists understand more about how drugs affect the brain and what happens while people are working on different activities (learning, language)

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Rett

________ syndrome: a rare neurodevelopmental disorder that affects the way the brain develops.

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Mutations

________: errors in the sequence and /or amount of DNA.

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particular neurotransmitter

Can be used to pinpoint the relationship between a(n) ________ and behavior or cognitive process.

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Positrons

________: positively- charged anti- electrons.

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Repetitive TMS

________ is used to investigate the role of specific brain regions during behavior.

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Levodopa

A drug that gets converted to dopamine in the brain.

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52

Then he turned to a simpler organism

the sea slug

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53

Amblyopia

A condition where the vision of one eye is greatly reduced because the eyes do not work well together.

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54

Electroencephalogram (EEG)

Electrodes are placed on the head and record the electrical activity of the brain in response to a variety of stimuli and activities.

New cards
55

Positrons

Positively-charged anti-electrons.

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56

Diffusion Tensor Imaging

An imaging technique that takes advantage of diffusion rates of water and shows connections in the brain.

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57

Functional Magnetic Resonance Imaging (fMRI)

Imaging that compares brain activity under resting and active conditions.

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58

Magnetoencephalography (MEG)

Imaging that reveals the source of weak magnetic fields emitted by neurons.

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59

Optical imaging

Imaging that relies on shining weak lasers through the skull to see brain activity.

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60

Near-infrared spectroscopy (NIRS)

Imaging that relies on shining lasers through the skull at near-Infrared frequencies.

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61

Diffuse optical tomography

Imaging used to create brain activity maps.

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62

Event-related optical signal

Imaging that records how light scatters in response to fast cellular changes that arise when neurons fire.

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63

Transcranial magnetic stimulation (TMS)

This induces electrical impulses in brain by altering magnetic fields through an electromagnetic coil held against the scalp that emits powerful magnetic pulses.

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64

Genes

Sections of DNA that code for a product.

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65

Mutations

Errors in the sequence and/or amount of DNA.

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66

Chromosome microarrays

A technique that looks carefully at the overall chromosome makeup of a person and finds out if segments of chromosomes or missing or duplicated.

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67

RBI

The gene that causes retinoblastoma.

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68

DMD

The gene that causes Duchenne muscular dystrophy.

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69

FMRI

The gene that is abnormal in those with fragile X syndrome.

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70

22q deletion syndrome

A condition where individuals are missing a part of chromosome 22.

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71

Tuberous sclerosis complex

A genetic disorder characterized by the growth of many benign tumors in the body.

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72

Rett syndrome

A rare neurodevelopmental disorder that affects the way the brain develops.

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