enzymes in mouth
amylase digests starch into smaller sugar molecules
what does the stomach contain
hydrochloric acid, helps enzymes to start digestion of protein
what does churning action in stomach do
turns the food into a fluid increasing the surface area for enzymes to digest
chemicals released in to ... from ...
small intestine from liver and pancreas
pancreas releases
enzymes continuing digestion of starch and protein, starts digestion of lipids
liver releases
bile neutralises acid released from stomach, as it is an alkaline solution, speeding up digestion of lipids by lipase
walls of small intestine release
enzymes continuing digestion of protein and lipids
small intestine, absorption
small food molecules broken down by digestion are absorbed into bloodstream through active transport or diffusion
large intestine
water absorbed into bloodstream
rectum
short tube at end of the large intestine, waste material is compressed into a solid form
anus
muscular opening at the end of the rectum, waste material is eliminated from the body
what are products of digestion used for
build new carbohydrates, lipids and proteins
some glucose is used in respiration
mouth enzymes
starch broken down by salivary amylase, produced by salivary glands, into maltose
starch is broken down by...into...
amylase into maltose
amylase is made in
salivary glands, pancreas, small intestine
proteins are broken down by...into...
protease into amino acids
protease is made in
stomach (pepsin), pancreas and small intestine
lipids are broken down by...into...
lipase into glycerol and fatty acids
lipase is made in
pancreas and small intestine
bile
emulsifies lipids into smaller droplets, massively increasing surface area of lipid droplets, increasing rate of lipid breakdown by lipase
at optimum pH or temp, enzymes have
max frequency of successful collisions between substrate and active site
test for starch
iodine solution -positive- blue black -negative- orange yellow
test for sugar glucose
benedict's solution, 5 min hot water bath green- small amount yellow- more brick red- lot
drawback of benedict solution
doesn't work on non-reducing sugars, e.g. sucrose
test for protein
buriet solution -positive- purple ring between layers -negative- no change
test for fats/lipids
sudan II, shake positive- red layer forms
test effect of pH on enzyme starch
one drop of iodine solution in spotting tile
3 test tubes, each containing same volume of starch solution, amylase solution, pH 5 solution buffer solution (used to control pH)
place 3 test tubes in water bath at 30 degrees C and leave for 10 mins to allow solutions to reach right temp
combine 3 solutions, mix using stirring rod
immediately return test tube to water bath and start stopwatch
after 30s, use stirring rod to transfer one drop of solution to spotting tile
iodine turns blue black showing starch is present
take sample every 30s until sample remains orange, telling us starch is no longer present and reaction is finished
stop stopwatch, record time taken
repeat experiment many times, using different pH buffers, e.g. 6,7,8
problems with effect of pH on enzyme amylase experiment
only taking samples every 30s means time recorded for reaction to take place is approximate. instead take samples every 10 seconds
looking for when iodine doesn't go blue black, not always obvious as colour change is gradual, hard to see when reaction finished. instead ask several people to look at spotting tile to decide when investigation is finished
small intestine adaptation
very long, 5m in an adult human, very large SA
small intestine interior is covered with millions of
millions of villi- massive increase SA
adaptation of villi
covered with microvilli further increase SA
very good blood supply, increase concentration gradient
villi have very thin membrame, short diffusion path
explain circulation in fish
single circulatory system-
deoxygenated blood goes from heart, to gills, where it gains oxygen, and then oxygenated blood passes straight to organs, oxygen diffuses out of blood into body cells, blood returns to heart
problem- blood loses pressure, as it passes through gills before reaching organs, blood can't travel as quickly to organs, meaning not as much oxygen is delivered
explain circulation in humans
double circulatory system-
deoxygenated blood enters right and left atrium of heart through vena cava, atriums contract forcing blood into ventricles, ventricles contract forcing blood out of heart, blood is pumped from heart to lungs through pulmonary artery, blood gains oxygen in lungs, oxygenated blood returns to heart through pulmonary vein, and then leaves the heart through the aorta and is transported to organs, diffusing oxygen from blood to body cells, then the deoxygenated blood re-enters the heart through the vena cava
benefit- blood passes through heart twice, pressure is not lost, travel rapidly to body cells delivering more oxygen
valves
between atrium and ventricles, prevent backflow of blood
left side of heart is
thicker muscular wall, left side pumps heart all around body where as right side only pumps to lungs
arteries
withstand high pressure from carrying blood, thick muscular walls
blood travels through in surges when heart beats, so elastic fibres stretch
in between surges, elastic fibres recoil, keeping blood moving
capillaries
allows substances, like glucose and oxygen to diffuse from blood into body cells. carbon dioxide diffuses from body cells to blood.
very thin wall- shorter diffusion path
veins
valves have very thin walls, carry low pressure blood
contain valves which prevent back flow of blood. when blood is flowing in the correct direction valves are open, when blood starts to flow backwards, valves close
what four things is blood made up of
plasma, red blood cells, white blood cells, platelets
plasma
liquid part of blood
transports:
soluble digestion products, e.g. glucose, from small intestine to other organs
carbon dioxide, from body cells to lungs, to be breathed out
waste product urea from liver to kidneys, to be excreted in urine
red blood cells
transport oxygen from lungs to body cell
adaptations:
haemoglobin, combines with oxygen to form oxyhaemoglobin, which is released in organs (oxygen released)
no nucleus, more space to carry haemoglobin
biconcave shape, greater SA, oxygen diffuses in and out rapidly
white blood cells
part of the immune system
adaptations:
nucleus containing DNA encoding instructions on how to do job
platelets
tiny fragments of cells, helps= blood clotting
why is blood clotting important?
it prevents excessive blood loss and the entry of microorganisms
uses of donated blood
replace lost blood, platelets to help clotting, proteins extracted useful in antibodies
lack of platelets leads to
excessive bleeding and brusing
problems of donated blood
blood transfusions- must have same blood type or it will be rejected from immune system and patient may die
lots of diseases can be transmitted, but in UK, blood is screened for infections so risk is very low
coronary arteries
branch from the aorta, and carry oxygen-rich blood to the heart muscle, oxygen is used in respiration, providing energy for contraction
drug treatment of coronary artery disease
statins- reduce cholesterol in blood, slows down rate that fatty material builds in coronary artery
they are effective, but can cause liver problems
physical treatment of coronary artery disease
stent- tube used to keep coronary arteries open
blood can flow normally, but won't prevent other areas of coronary arteries flowing, and won't treat underlying causes
faulty valves can happen because
they do not fully open, heart has to pump extra hard to get the blood through, causing heart to enlarge
leaky valves causes patient to feel weak and tired0
treatment for faulty valves
mechanical valve- last a life time, but increase risk of blood clots, patient take anti-clotting drugs
valve from animal- don't last as long, patients don't have to take drugs
heart failure
heart of patients with cardiovascular diseases cannot pump enough blood around the body
heart failure treatment
donated heart and/or lungs
problems with heart donation
not enough hearts available to treat every patient, patient must take drugs to stop donated heart being rejected by immune system
temporary heart failure treatment
artificial heart, while waiting for a heart transplant, or allowing damaged heart to rest
downsides of artificial heart
increase risk of blood clotting, not a permanent solution as can only be used for relatively short amount of time
air passes into lungs through
trachea
trachea has
cartilage rings preventing it from collapsing when we inhale
in the alveoli, oxygen diffuses
in to blood stream
In the alveoli, carbon dioxide diffuses
out of the blood and into the air
alveoli has
very thin walls, meaning diffusion path is very short
alveoli have a
very good blood supply, meaning once oxygen diffuses in to blood it is rapidly removed, meaning concentration gradient is very steep
alveoli has a large surface area because
there are millions of tiny alveoli
breathing increases
rate of diffusion, as it brings fresh oxygen into alveoli and takes away carbon dioxide, meaning the concentration gradient is high
benign tumours are
contained within a membrane
malignant tumours...
invade neighbouring tissue and move into bloodstream, forming secondary tumours
increased risk of lung cancer is caused by
radon- radioactive gas, it releases ionising radiation which damages DNA in cells, causing uncontrolled cell division, leading to cancer
what is TB
communicable lung disease
health
state of physical and mental well-being
when is TB fatal
when someone has a weak immune system, e.g. someone with HIV
someone with a weak immune system is more likely to
suffer from infectious diseases
HPV is usually
essentially harmless
an example of one disease being the cause of another is
HPV causing cervical cancer in some people
disease triggered by immune system
allergies, e.g athsma or dermatitis
body is infected with pathogen, which immune system fights off, but person is left with allergy
an example of mental illness triggering physical illness
arthritis leading to depression
epideiology
scientific study of the patterns of disease to determine risk factors
correlation does not
prove cause, but suggests they may be linked
what in cigarettes causes damage to DNA and increases risk of cancer
chemical called carcinogens
causal mechanism
something that explains how one factor influences another
to avoid bias, sample must be
as large and random as possible
why can't we draw conclusion about entire population from a small and non-random sample
a place may be exposed to more/less radiation, or the people may get more/less exercise
high fat low veg diet leads to
increase of cholesterol levels in blood, increasing rate if fatty acid build up in artery, increasing risk of cardiovascular diseases
high salt diet leads to
increase in blood pressure, increasing risk of cardiovascular diseases
exercise lowers risk of
cardiovascular diseases
smoking when pregnant
increases risk of miscarriage, premature birth, low body mass of baby
drinking when pregnant
increases risk of fetal alcohol syndrome, leading to learning difficulties, and other mental and physical problems
alcohol affects on brain
addiction and memory loss
type 2 diabetes can lead to
blindness or amputation of a limb
epidermal cells
form epidermal tissue, protects surface of leaf
upper epidermis
transparent so light can pass through it to reach the photosynthetic cells. covered with waxy cuticle, which reduces evaporation from surface of leaf, prevents leaf from drying out
lower epidermis
stomata- allows carbon dioxide to enter leaf and oxygen to leave. also controls water vapour that passes out of leaf. controlled by guard cells
pallisade mesophyll
palisade cells equipped with lots of chloroplasts which contain chlorophyll to absorb sunlight for photosynthesis
spongy mesophyll
full of air space, allowing carbon dioxide to diffuse through spongy mesophyll to palisade cells. oxygen diffuses the other way
magnesium use in plants
making chlorophyll
translocation
movement of sugars and other molecules through phloem tissue
transpitation
water constantly evaporated from surface of leaves
transpiration
water loss (vapor) through stomata open for gas exchange
factors affecting transpiration
faster when - higher temp
dry conditions because this is when evaporation works faster
windy because wind removes any water vapour allowing for quicker evaporation
high light intensity because this increases rate of photosynthesis, so stomata open allowing carbon dioxide enter, so water vapour can pass out of leaf
when light intensity is high
guard cells swell and change their shape, causes stomata to open. now co² can diffuse into leaf and be used in photosynthesis